To cause to serve a purpose other than the original or. To undermine, overturn, or render ineffective (a rule or an established notion, such as a stereotype, for example). system by attacking it secretly or indirectly. To overthrow or destroy (a government or an established order or authority). This article is part of a Special Issue entitled Mitochondria: the deadly organelle.Ĭopyright © 2010 Elsevier B.V. 1transitive, intransitive subvert (something) to try to destroy the authority of a political, religious, etc. In this review, we highlight the viral proteins that are specifically targeted to the mitochondria to subvert host defense. Thus, it is therefore not surprising that this organelle represents a recurrent target for viruses, aiming to manipulate the fate of the infected host cell or to inhibit innate immune response. Nondemocratic governments often claim that anyone who disagrees with them or joins a demonstration is a subversive. When you subvert something, your words or actions criticize or undermine the usual way of doing something or common values. government, though they often saw subversive activities where none existed. Subvert a process definition: To subvert something means to destroy its power and influence. In the 1950s and '60s, many people worried about communist subversion of the U.S. Mitochondria have been long recognized for their key role in the modulation of apoptosis but more recently, mitochondria have been shown to serve as a crucial platform for innate immune signaling as illustrated by the identification of MAVS. Subversion is literally the 'turning over' of something. Conversely, induction of apoptosis may favor viral dissemination as a result of the dismantlement of the infected cells. To subvert an institution like a school or a government is to overthrow it or stop its normal way of functioning. The girl who wears a tuxedo to the prom might subvert traditional ideas about beauty. Our best intentions are sometimes subverted by our natural tendency to selfishness. When you subvert something, your words or actions criticize or undermine the usual way of doing something or common values. Throughout the process of pathogen-host co-evolution, viruses have therefore acquired the capability to prevent host cell apoptosis because elimination of infected cells via apoptosis is one of the most ancestral defense mechanism against infection. subvert verb T formal uk / sbvt / us / sbvt / to try to destroy or damage something, especially an established political system The rebel army is attempting to subvert the government. Viruses have developed a battery of distinct strategies to overcome the very sophisticated defense mechanisms of the infected host.
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